It all depend upon if you are able to keep it out of detonation. That involves good fuel and pulling PLENTY of timing out. A stock block will take a lot.... as long as you don't push the tune too far and run it into detonation.
Way back when, I helped a friend of mine built a 426ci 351W stroker. It was build using a 1978 block, turned down 400M crank, Chrysler rods, and dished Probe pistons. (stuff used before inexpensive Chinese parts hit the market) It was outfitted with a set of the original High Port TFS heads that were majorly ported, along with a hogged out Victor Jr. It was outfitted with a 2-stage Top Gun nitrous system and installed in a 3000lb w/driver 1989 mustang running. It ran MT 28x10.5 slicks. This car was pushed to a 5.92 @ 121mph in the 1/8. The engine lasted through two years of this before it was sold to a friend who installed a different set of heads and ran it naturally aspirated for quite some time.
What made it live was that fact that it was kept out of detonation. Detonation is what kills marginal parts. If left unchecked, it will kill good parts too. The compression ratio of this engine was only around 11:1. PLENTY of timing was pulled out for the nitrous, and good fuel was always used. Plus, the engine didn't even need to be revved hard. It was usually shifted at 6k-6.2k rpm. The rear was an 8.8 fitted with 3.73 gears. Without the nitrous, it would run just fine on pump gas, never heated up, and was exremely streetable.
Here's a picture of it at the track.
He later went to a Motorsport block, high compression, bigger heads, tubbed it out, etc. The car then went low 5's. Somebody else gave him some bad tuning advice, and it turned into a hunk of junk parts.
Avoiding detonation is KEY. Do this, keep the rpm within reason, use a reasonable 200-250hp shot of juice, and it should last a long time.
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